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Structurally, Dihexa is derived from angiotensin IV a naturally occurring peptide involved in brain function but has been chemically modified to dramatically enhance its potency and its ability to penetrate the blood-brain barrier

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As hinted above, this predicament could be disentangled via studies that include a mechanistic assessment of biomarkers predicting response versus harm following GLP-1RA administration 192

Ongoing Innovation: Companies should continue to innovate and seek new indications and formulations (such as combination therapies) to broaden the scope of GLP-1 receptor agonists

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