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Schizandrol A promoted the activation of PI3K/Akt in acute myocardial ischemia mice and H9c2 cells treated with oxygenglucose deprivation, downregulated the expression of NOX2, as well as significantly reduced myocardial infarction area and improved biochemical indicators and cardiac pathological changes, thus exerting cardiac protective effects (50)
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13b, c)
Lilly's dual GIP/GLP-1 receptor agonist mechanism represents a distinct pharmacological approach with comparable efficacy demonstrated in randomized controlled trials published in major medical journals
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