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10.1161/CIRCRESAHA.117.311002 12

MC4R receptor desensitization occurs after 710 days of consistent dosing, reducing nausea intensity long-term independent of timing

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In Phase 2, participants were randomized to multiple doses, such as: 1 mg fixed dose 4 mg, starting at 2 mg or 4 mg 8 mg, starting at 2 mg or 4 mg 12 mg, starting at 2 mg All doses were administered subcutaneously once weekly, and dose escalation was intended to improve tolerability