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The Gq/11 pathway activates phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into IP3 and diacylglycerol (DAG)

Walking uses muscles, but it does not challenge them against enough resistance to trigger the muscle protein synthesis response that protects lean mass during caloric restriction

The future exploration of role of LEAP2 in the expression and function of other glucose-regulatory hormones, such as GLP-1, GIP, and glucagon, is intriguing

Insulin has been the recommended ADM during pregnancy, as it does not cross the placenta and is, therefore, unlikely to cause malformations