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Collectively, these data reveal a stress-adapted, senescence-like DAO state specific to CPZ-induced demyelination that recapitulates key transcriptional features of OLs enriched in MS lesions

To determine the oxidative stress at membrane level, we used a quantitative assay based on the intracellular production of MDA measured by the commercial kit LPO-586 (Oxis Health Research Products Portland, OR, USA)