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There is also a 5-year Phase III clinical trial (NCT04822181) underway to investigate the efficacy and safety of semaglutide monotherapy in patients with NASH without cirrhosis, assessing the primary endpoints of progression of cirrhosis, regression of steatohepatitis, inflammation, and histological changes in balloon-like hepatocytes
Then, it involves other set of the genes ( Braf, Egfr, Egr1, Hdac7, Mapk1, Mapk3, Mapk14, Plcg1, Prkcg, Ptk2, Pxn, Src, Srf, and Vegfa )
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Connelly, P
Currently approved GLP-1 therapies are primarily peptide-based injectables, with once-weekly administration being the main approach
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