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No, degradation is gradual
10.1016/J.BBRC.2018.08.171 13 BenagliaL.CardellicchioL.FilippiF.PaffoniA.VercelliniP.SomiglianaE.et al (2014)
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Participants in the intervention and placebo groups followed an identical 16-week dose escalation protocol, titrating up to a dose of 2.4 mg weekly or maximal tolerated dose
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