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10.1016/j.immuni.2010.08.014 218 PrezM
Phase 2 trials published in the New England Journal of Medicine showed participants losing an average of 24.2% of their body weight at the 12mg weekly dose over 48 weeks
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Notably, Cagrilintide activated fewer neurons overall than sCT, particularly in the AP by 75% and LPBN by 36%, suggesting differences in their receptor selectivity and downstream signaling dynamics [2]
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