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The direct availability of B12 via injections accelerates absorption, enhancing energy, mental focus, and stress reduction
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Bioavailability is lower than injection
This effect is particularly relevant in hypogonadal models and aging populations where GH-axis activity declines
A phase II trial focusing on individuals with overweight or obesity, coupled with hypertension or dyslipidemia but without T2D, found that cagrilintide (2.4 mg) alongside diet and exercise, led to a 10% body weight reduction compared to 3% with placebo over 26 weeks [99]
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