Patients and trial participants should be aware of the following red flag symptoms that require urgent review: Dysphagia (difficulty swallowing) or odynophagia (painful swallowing) Unexplained weight loss beyond that expected from the medication Persistent vomiting or an inability to keep fluids down Haematemesis (vomiting blood) or melaena (black, tarry stools) Severe or worsening chest pain if you experience severe chest pain, particularly with breathlessness, sweating, or pain radiating to the arm or jaw, call 999 immediately , as these may indicate a cardiac emergency rather than a digestive cause Symptoms that persist despite appropriate self-management , or that significantly affect daily life These symptoms may indicate more serious conditions such as oesophagitis, peptic ulceration, or, in rare cases, upper GI pathology requiring endoscopic investigation

[7] [8] It turned out that this effect was due to a small peptide factor that behaved similarly to the synthetic peptide glycyl-L-histidyl-L-lysine (GHK)
Hershman, Dr
Among them, -3 PUFAs (EPA and DHA) and polyphenols (curcumin) are regarded as key nutrients with potent anti-inflammatory effects, and also the main effect components in the recommended dietary pattern, MD
Moore, P