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In a phase 1, randomized, double-blind, placebo-controlled clinical study in participants with obesity (NCT04478708), AMG 133 had an acceptable safety and tolerability profile along with pronounced dose-dependent weight loss
Moreover, studies suggest that dual and triple receptor agonists may have additional effects on histological NASH features vs high-dose GLP-1R agonists alone, and that these may be independent of changes in body weight [78]
Calendar routines and reminders: Make sure to align the dosing time according to your social or work commitments
A net positive
Why this matters: Very low calorie intake = fatigue, Lack of nutrients can slow metabolism Increases risk of muscle loss Focus on: Protein: supports muscle and energy Fiber: prevents constipation Balanced meals: even in small portions What to avoid: Skipping meals completely Eating only once a day Relying on junk or liquid calories Simple rule: Eat less, but eat smart 5
