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In SURMOUNT-4, participants who switched from tirzepatide to placebo regained more than 50% of their lost weight over 52 weeks

Worth every bit of the adjustment period

These findings align with a model in which ERR activation restores mitochondrial oxidative capacity and lipid flux in hepatocytes, contributing to reversal of steatotic features

Other health conditions that could be helped by weight-loss medications may be left untreated, particularly when it comes to secondary diseases such as diabetes, CVD, hypertension, as well as skeleton muscular issues like hip or knee joint issues, Schabacker said

That broader perspective helps us keep the conversation grounded in what the patient is actually experiencing