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Mechanism research remains active
The right concentration depends on your current dose, your titration plan, and your comfort with small-volume measurements
Key findings at the highest dose (12mg weekly): Up to 24% mean body weight reduction over 48 weeks Significant reductions in fasting glucose and insulin resistance markers Meaningful reductions in liver fat content, relevant for participants with metabolic-associated fatty liver disease Once-weekly subcutaneous dosing was generally well-tolerated For context, semaglutide at its approved dose achieves approximately 1517% body weight reduction over 68 weeks
These medications truly target metabolic health in a holistic way weight loss is the primary goal, but the ripple effects on overall health are hugely beneficial
Cell Biol Toxicol 40 , 80 (2024)
