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However, when fatty acid delivery exceeds mitochondrial oxidative and redox-buffering capacity, increased electron transport pressure can elevate reactive oxygen species (ROS) production, promote endoplasmic reticulum stress, and increase susceptibility to lipid peroxidation [54, 61,62,63]
Na een jaar gebruikt ongeveer de helft van de diabetespatinten het medicijn nog, en na twee jaar is dat minder dan de helft
Slow or Non-Responders: Not everyone experiences dramatic benefits
However, the FDA recommends that treatment should be stopped if a patient cannot tolerate the 3 mg dose because lower doses (0.6, 1.2, 1.8, and 2.4 mg) have not been shown to be effective
While the activity of ETC components decreases following TBI, evidence regarding the activity of complex II, which accepts electrons from ketones, varies and may not show as significant inhibition as other complexes [72, 84]
