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SIN attenuates amyloid -induced astrocytic activation, reduce the release of ROS and inflammatory mediators, and protect both rodent and human neurons against indirect toxicity, suggesting its broader neuroprotective potential in neurodegenerative conditions (143)

General function: Involved in RNA binding Specific function: Methylates cytosine to m5C at several positions in different tRNAs and pre-tRNAs containing intron

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First, traditional treatment is based on calorie restriction with or without physical activity