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Hyperglycaemia (as a marker of defective glucose homeostasis) is a fundamental feature linked to retinopathic, neuropathic and nephropathic complications, and a contributing risk for associated morbidities, particularly cardiovascular diseases

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Among these core components, BBS5 is a compelling target for investigation, as it is highly conserved (4) and plays a critical role in ciliary protein trafficking (2, 5), but it remains an understudied component of the BBSome (6)