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Severe Obesity and Established Cardiovascular Disease TRIUMPH-3 (NCT05882045) evaluated 1,949 adults with Class II or Class III obesity (body mass index of at least 35 kg/m) and established cardiovascular disease, with or without type 2 diabetes

The central evidence gap The compound has an interesting biological target and a growing mouse-research record

CagriSema was identified as the most effective GLP-1RA compared with placebo in reducing body weight in adults with type 2 diabetes

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Ibuprofen can reduce glomerular filtration rate, particularly in patients with pre-existing chronic kidney disease, volume depletion, or heart failure