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The peptide activates the melanocortin-4 receptor (MC4R), which plays a central role in integrating signals about energy status and coordinating appropriate metabolic responses
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This endothelial dysfunction decreases the potent vasodilator nitric oxide (NO) in endothelial and vascular muscle smooth cells, increases the levels of vasoconstrictors such as endothelin-1 [13], and creates a hypercoagulable state by activating platelet aggregation and inhibiting fibrinolysis [14]
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