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Research suggests that cycling protocols (3-6 months on, 1-2 months off) provide the best balance of effectiveness and long-term safety for extended research uses
Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible
NNMT pathway research, NAD metabolism models, metabolic signaling studies
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