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i.e., insulins and analogues, biguanides, sulfonylureas, alpha-glucosidase inhibitors, thiazolidinediones, DPP-4is, GLP-1 RAs, sodium-glucose co-transporter 2 inhibitors, and repaglinide

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The critical factor is the cumulative time outside the fridge

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The better question is: How can you support the bodys natural metabolic systems as well as possible