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Initially indicated for the management of type 2 diabetes, significant weight-loss was seen

To lower CV risk in type 2 diabetes and CKD, the standards recommend an SGLT2 inhibitor, a nonsteroidal mineralocorticoid receptor antagonist such as finerenone or a GLP-1 receptor agonist

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We show that GLP-1(2836) entered mouse caSMCs and ECs by macropinocytosis and activated sAC, as evidenced by the increased production of cAMP in caSMCs from WT but not sAC / mice