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Disparities in the quantity and percentage of the documented psychiatric AEs among different GLP-1 RAs could potentially be associated with factors such as their duration in the market (e.g., more time for AEs to be reported into FAERS for medications that have been available for longer), clinical utilization, and specific drug characteristics

Emerging evidence suggests GLP-1s may hold promise as an added therapeutic option, but further clinical trials in humans are necessary to determine the safety, efficacy, and role in addiction treatment