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The beneficial behavior of the bacteria can be attributed to a protein MtcB, that aids in the demethylation process that involves the removal of one methyl group, to change a compounds structure or function, thereby reducing the toxicity of TMA

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Activated CAFs secrete cytokines such as IL-6 and TGF-, remodel the ECM to create physical barriers, and promote immune evasion through paracrine signaling ( 2.2 Immune evasion mechanisms at the cellular and molecular level osteosarcoma employ multiple strategies to evade immune recognition and destruction

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