There are alternative medications for addressing obesity and type 2 diabetes
For example, researchers have found that HRAS V 12 expressing cancer cells are electively sensitive to ferroptosis, and KRAS silencing in KRAS mutant Calu-1 cells strongly reduces erastin sensibility (Yagoda et al., 2007)
In patients with T2DM and other metabolic abnormalities, elevated SELENOP levels exacerbate IR and reduce the efficiency of insulin transport into the CNS, thereby compounding metabolic dysfunction and possibly contributing to neurodegenerative processes [224]
Notably, certain metabolites may exhibit context-dependent functional polarity, where even the same metabolite can produce opposing effects depending on experimental conditions, dosage regimens, or disease stages
So what exactly is its function