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Several small observational studies report subjective improvements in hair thickness or reduced shedding among users, but these lack placebo controls and standardized measurement protocols

For example, most men taking exogenous androgens (like testosterone injections) have profound decreases in sperm production, but a relatively small percentage ( 6 months) use can lead to decreases in sperm counts and quality in some men

Most of the available evidence is still preclinical, meaning it comes from cell studies, animal models, or specialized delivery-system research rather than large human trials