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One quick answer is calorie restriction or some form of it
When using a HP-B-CD instead, virtually no increase is observed during the 35 days duration of the study
Others who choose to take pills or subdermal supplements may notice a more gradual effect, sometimes taking a few weeks before their symptoms improve
doi: 10.1021/acsomega.0c02125 25 HommaT.FujiiJ
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