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Sitagliptin works ONLY when blood sugar is elevated, to address diminished insulin levels due to -cell dysfunction and uncontrolled production of glucose by the liver (due to pancreatic -cell and -cell dysfunction) Figure
When gastroparesis occurs, the stomach is slow to empty, resulting in persistent symptoms like nausea, vomiting undigested food, abdominal pain, abdominal bloating, severe dehydration, feeling full after only a few bites, undigested food hardening in the stomach, acid reflux, fluctuating blood sugar levels, lack of appetite, weight loss, malnutrition and decreased quality of life
With respect to the previously mentioned study, this proof-of concept study has important methodological strengths residing in the availability of baseline and post-treatment hepatic biopsies
