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Increased G6PD activity has been reported in various neoplasms, including hepatocellular cancer, leukemia, colorectal cancer, breast tumors, renal cell carcinomas, and gastrointestinal cancers (1520)

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This indicates that a substantial portion of EC and its conjugates reaches the colon unabsorbed, where microbial enzymes cleave glycosidic linkages and initiate catabolic conversion into ring-opened and chain-shortened phenolic acids

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