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Improper technique or contamination can lead to more serious localized issues such as injection site infection, abscess formation, tissue necrosis, or thrombophlebitis (vein inflammation)

In 2025, the European Medicines Agency concluded that NAION should be listed as a very rare side effect of semaglutide medications, including Ozempic, Wegovy, and Rybelsus, after reviewing clinical studies, adverse event reports, and post-market safety data

See our research peptides legal guide for the regulatory framework

Consistency and personal health status also play an important role in the timeline

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