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Following cytosolic uptake, iron is transported into mitochondria by Leishmania mitoferrin 1 (LMIT1) (75), where enzymes including coproporphyrinogen oxidase, protoporphyrinogen oxidase, and ferrochelatase, contribute to heme biosynthesis from host-derived precursors (66, 76, 77)

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circ0088036 is found to be aberrantly upregulated in RA FLS, and it facilitates RA progression by acting as a miR-140-3p sponge to upregulate SIRT 1 expression (273)

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