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Figlioli G., et al

Because Ozempic helps insulin development, insulin resistance may also contribute to Ozempic weight gain, according to Giese: the more insulin-resistant a patient taking Ozempic is, the more insulin is produced, which can lead to weight gain since insulin promotes fat storage

PMID 12467574

Policy debates on GLP-1 pills

Common side effects reported with retatrutide include: Nausea, vomiting, and diarrhoea (most frequent, particularly during dose escalation) Decreased appetite Constipation Injection site reactions Mild increases in heart rate Cagrilintide has demonstrated a generally well-tolerated profile, with gastrointestinal symptoms also being the most commonly reported adverse effects