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Importantly, these effects could be recapitulated in cysteine desulfurase (NFS1) knockdown cells with impaired iron-sulfur cluster synthesis, indicating that phenotypes observed in SLC25A39/40 knockout cells are likely a consequence of an iron-sulfur cluster deficiency (Extended Data Fig

Genome Res 19:15071515 Tujios S, Fontana RJ (2011) Mechanisms of drug-induced liver injury: from bedside to bench