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Figure 2 MAPKs are a group of conserved serine/threonine protein kinases, including ERK, JNK, and p38

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For instance, both diabetic and non-diabetic women with insulin resistance have higher risk to develop breast, endometrial and ovarian cancer, and results from studies in ovarian and cervical cancer suggest that the first-line type 2 diabetes drug and anti-insulin resistance agent metformin is a good candidate in combination therapies for these cancers (4, 9)