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In a multicenter randomized trial, NAC combined with metformin improved liver measures in non-alcoholic steatohepatitis over several months, supporting its role as an add-on to standard care rather than a replacement.[3]NAC in NASH Randomized Trial PubMed View source A more recent double-blind trial in metabolic-associated fatty liver disease also reported improvements in liver function and metabolic markers with NAC, adding to the promising but still-developing evidence base.[4]NAC on Liver Function in MASLD RCT PubMed View source Liver enzymes: modest ALT and AST reductions in trials

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in the LEADER, REWIND, EXSCEL, ELIXA and SUSTAIN-6 trials were no significant difference in HF hospitalization between GLP-1 receptor agonist and placebo group ( However, meta-analysis encompassing eight CVOTs showed positive impact of GLP-1 receptor agonists on heart failure in patients with type 2 diabetes (T2D)