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GLP-1 RAs, in contrast have reported a weight reduction of up to 20% of the patients body weight (Kristensen et al., 2019

What Both Medications Do Inside the Body Although the delivery systems differ, both medications activate the GLP-1 receptor and trigger similar downstream effects: Increased insulin release in response to elevated blood sugar Reduced glucagon secretion Slower gastric emptying Reduced appetite signaling Increased satiety after meals According to the National Institute of Diabetes and Digestive and Kidney Diseases, these mechanisms can support improved blood sugar regulation and meaningful weight reduction when combined with lifestyle interventions

Chronic use of high-dose supplements can potentially affect blood sugar regulation, promote abnormal tissue growth, and contribute to joint and nerve issues

The long-term safety of inhaled GLP-1 also needs to be established since GLP-1 receptors are abundantly expressed in pulmonary tissue

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