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Phenotypic switching in Candida glabrata involves phase-specific regulation of the metallothionein gene MT-II and the newly discovered hemolysin gene HLP

Severe dehydration can lead to dizziness, weakness, kidney injury, low blood pressure, electrolyte imbalance, cardiac complications, and hospitalization requiring intravenous fluids or nutritional support

If the weekly maintenance dose of 1mg does not provide adequate control, the dose maybe increased up to 2.0 mg per week, based on the patients response and tolerance

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As a result, low doses often lose effectiveness over months