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Materials and Methods Materials Rapamycin (Rapa) was purchased from Tocris Bioscience (Bristol, UK)

W e described the task assigned to thepeuteiro (the person in charge of suggesting h o w the content of the materials to be published should be presented), explained the rules applying to titles and captions, and identified the basic elements that go to m a k e up a news item (who, what, when, h o w , where and why)

DKD patients exhibit significant structural dysbiosis of gut microbiota, characterized by decreased abundance of beneficial bacteria producing short-chain fatty acids (SCFAs) and increased abundance of harmful bacteria generating uremic toxin precursors (12)

Furthermore, long-term redox disturbances and interactions with endogenous antioxidant systems are often under-evaluated