10.1016/S0140-6736(19)31762-3 82
The session covers equipment setup, dose calculation from the reconstitution chart, site selection for the specific protocol, and a supervised practice injection so patients can feel the correct technique before doing it alone at home
Conversely, in a recent randomized, double-blind, placebo-controlled study involving twenty healthy volunteers, a once-weekly injection of a GLP-1R agonist, dulaglutide, for three weeks did not influence HPA axis activity, showing no significant effects on circadian rhythms of blood or salivary cortisol secretion, and the level of this hormone also was not changed after the dexamethasone suppression test in comparison with the placebo-receiving group [78]
So administering native IGF-1 in a research protocol means working with a compound thats rapidly cleared and rapidly sequestered
However, those are by no means the only proven health benefits that semaglutide offers to patients