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Transport of ALCAR across cell membranes, including the blood-brain barrier, is primarily mediated by the organic cation/carnitine transporter 2 (OCTN2, encoded by SLC22A5), a sodium-dependent transporter expressed on the luminal side of endothelial cells [5]
Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice
One explanation for this appears to be a negative-feedback inhibition of L-cell secretion by the elevated levels of active GLP-1 brought about by DPP-IV inhibition (47), an effect which may be mediated by a paracrine action of somatostatin secreted from neighboring D-cells in the gut (97, 98)
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