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(2021) demonstrated that MOTS-c levels decline with age in both mice and humans, and that exogenous MOTS-c administration improved physical capacity in aged mice without observable toxicity over a 2-week treatment window [5]

Currently, we have a poor understanding of how sea urchins can maintain this downregulated state for periods of years when other marine invertebrates, such as abalone undergo complete starvation (no kelp provided) for up to 13 months before mortality occurs 30

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Type 2 diabetes, in particular, has seen a continuous increase in prevalence, driven by lifestyle shifts and population aging, especially in Westernized societies, where these factors contribute to rising obesity rates

Plant Physiol 141(2):384390