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However, these observations have not been confirmed in large-scale human trials
Options include dose adjustment, switching routes (injection to nasal or the reverse), trying a combination preparation, or pursuing a different intervention
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Finally, given that clinician-driven dose changes were allowed for participants on both IR-Tac and LCPT, some participants may not have been at steady state on day 7 or 14, which may have underestimated t 1/2eff
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