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[Polygonaceae], induces apoptosis through a caspase-dependent pathway (Shi et al., 2008)

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The specific inhibitor of ferroptosis, known as ferrostatin-1 (Fer-1), exerts a suppressive effect on osteoblast susceptibility to ferroptosis by elevating the expression of GPX4, thereby rescuing their osteogenic function and effectively halting the progression of peri-prosthesis osteolysis

Overall, glutathione is considered to have a favorable safety profile when used as directed, but the long-term safety of high-dose or chronic use has not been fully established