Translation to human clinical application has been narrower than the breadth of the preclinical literature would suggest
Nascobal Dosage and Administration 2.1 Testing and Other Considerations Prior to Dosing Prior to treatment, obtain hematocrit, reticulocyte count, vitamin B12, folate, and iron levels [see Dosage and Administration (2.4)]
Precautions and contraindications While no absolute contraindications have been established in the research literature, standard precautions apply: Pregnancy and nursing have not been studied, and ARA-290 should be avoided in these populations until safety data becomes available
Required laboratory preparation materials, including Bacteriostatic Water and Preparation Kits, are available separately
The vial should be gently swirled never shaken until the powder is fully dissolved