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The Scientific Controversy DSIPs history includes a fascinating scientific debate

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10.1038/s41598-020-76456-w Sci

That said, when using ingredients like tretinoin or GHK-Cu, which can increase photosensitivity, we want to avoid overexposure or burning

The authors suggested that as they only considered these types of manipulations from certain image types, the actual level of image fraud in scientific papers is likely much higher (Bik, Casadevall & Fang, 2016)