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No existing neuropathy treatment has demonstrated actual nerve fiber regeneration in human clinical trials at this scale
Although often presented as a broadly beneficial polyphenol, resveratrol has also been repeatedly flagged as a potentially PAINS-susceptible molecule, owing to its redox activity, metal-chelating properties, and tendency to interfere with multiple assay formats in a non-specific manner as highlighted in the Nature commentary ( Weight of evidence: Overall evidence is Low : an add-on signal on hyperactivity without core-symptom change
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doi: 10.1083/jcb.200809125 52 HttemannMLeeIGrossmanLIDoanJWSandersonTH
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