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No, they're sugar-free and designed to be weight-loss-friendly
27-34 Of note, several trials in the PIONEER program used two estimands to further distinguish their analyses: 1) a treatment-policy estimand, which used data collected at the end of the study period (e.g., week 26 or 52) in the analysis regardless of treatment discontinuation or use of rescue medication
While the precise reason has not yet been determined, its most likely a side effect of the weight loss itself, not the medication
Proposed mechanisms include tyrosinase inhibition and altered DOPA metabolism
And, this individual impact is good for the economy
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