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Bes F, Hofman W, Schuur J, Van Boxtel C

GLP-1 receptor agonists also influence your sympathetic nervous system and thermogenic pathways

GLP-1 agonists bind to the GLP-1 receptor and stimulate it to produce a physiological response, such as an increase in insulin sensitivity or appetite suppression

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Published transdermal research on berberine specifically - including a 2018 study in PLOS ONE - which found that carefully engineered pharmaceutical-grade transdermal preparations achieved meaningful bioavailability