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2020 Jan 30;25(3):609

It was suggested that the expression of the pro-inflammatory cytokines and chemokines, including IL6, IL1, and TNF, are due to activated NFB transfers to the nucleus of the liver cell and binds to their DNA

Paul et al

It is important to note that this mechanism, while biologically plausible, is not yet validated by large-scale controlled trials, and individual results vary considerably depending on baseline melanin levels, skin type, and dosage