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The final step in establishing preclinical proof-of-hypothesis was made when the results of these acute studies were recapitulated with chronic dosing, showing that the beneficial pancreatic islet and glucose-lowering effects of DPP-4 inhibition persisted over several months of treatment (30, 31)

Once reconstituted with bacteriostatic water, stability drops dramatically: even under ideal refrigeration (28C), the peptide loses 58% potency weekly through oxidative methionine degradation