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Liraglutide exerts anti-catabolic effect in murine primary chondrocytes in vitro To explore the inhibitory effect of liraglutide on the production of catabolic mediators, IL-1-stimulated chondrocytes were cultured with 2 ng/mL of IL-1 and 10 ascending doses (6.6, 13.3, 26.6, 53.1, 106.3, 212.5, 425, 850 nM, 1.7 and 3.4 M) of liraglutide for 24 h for IC 50 determination
The difference is not marginal
Studies found that intrathecal injection of GLP-1RAs effectively reduced formalin-induced peripheral nerve injury, as well as cancer- and diabetes-induced pain without causing serious adverse reactions
Subject to provider availability What brain-based arousal delivers Specific outcomes
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